Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor‑1α ABSTRACT Radiation therapy can result in severe side-effects, including the development of radiation resistance. The aim of this study was to validate the use of oxygen nanobubble water to overcome resistance to radiation in cancer cell lines via the suppression of the hypoxia-inducible factor 1-α

A major obstacle in effectively treating certain cancers is a condition known as hypoxia, where tumor cells are starved of oxygen and consequently become resistant to conventional treatments like radiation and chemotherapy. When this happens in practice, a doctor typically increases the radiation dose or the concentration of the chemotherapy drug, which often adversely affects the patient. University of Illinois at Urbana-Champaign Bioengineering Professor
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