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Abstract

Summary

Oxygen ultra-fine bubbles (OUB) saline injection prevents bone loss of glucocorti\coid-induced osteoporosis in mice, and OUB inhibit osteoclastogenesis via RANK-TRAF6-c-Fos-NFATc1 signaling and RANK-p38 MAPK signaling in vitro.

Introduction

Ultra-fine bubbles (<200 nm in diameter) have several unique properties, and they are tested in various medical fields. The purpose of this study was to investigate the effects of oxygen ultra-fine bubbles (OUB) on glucocorticoid-induced osteoporosis (GIO) model mice.

Abstract

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Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor‑1α

ABSTRACT

Radiation therapy can result in severe side-effects, including the development of radiation resistance. The aim of this study was to validate the use of oxygen nanobubble water to overcome resistance to radiation in cancer cell lines via the suppression of the hypoxia-inducible factor 1-α (HIF‑1α) subunit. Oxygen nanobubble water was created using a newly developed method to produce nanobubbles

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A major obstacle in effectively treating certain cancers is a condition known as hypoxia, where tumor cells are starved of oxygen and consequently become resistant to conventional treatments like radiation and chemotherapy. When this happens in practice, a doctor typically increases the radiation dose or the concentration of the chemotherapy drug, which often adversely affects the patient.

University of Illinois at Urbana-Champaign Bioengineering Professor Joseph Irudayaraj and his team have recently developed a nanotechnology-based platform that delivers oxygen to the diseased cells and helps restore the effectiveness of the cancer treatment. Joseph Irudayaraj Joseph Irudayaraj

“Cells in the hypoxic state are two- to three-times less receptive to treatments like radiation and chemotherapy,” noted Irudayaraj, the Founder Professor in Bioengineering, who holds appointments in the Carl Woese Institute for Genomic Biology and Micro + Nanotechnology Lab on campus. “If our technology can even decrease the radiation dose by 20%, then that’s effective.”

Irudayaraj and his research team created injectable nano-size oxygen bubbles made of FDA-approved cellulose compounds that are bio-compatible. In a study published in Nature Scientific Reports, they injected the 80-500 nanometer-size nanobubbles in mouse models with cervical cancer (HeLa) and bladder cancer (MB49) tumors.